Elucidating the Role of gpW: an Essential Baseplate Protein in Bacteriophage P2
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Mutational Analysis of the Downhill Folding Protein Gpw: towards Tuning Stability of a Molecular Rheostat Candidate
Title: MUTATIONAL ANALYSIS OF THE DOWNHILL FOLDING PROTEIN GPW: TOWARDS TUNING STABILITY OF A MOLECULAR RHEOSTAT CANDIDATE Adam Fung, Ph.D., 2008 Directed By: Associate Professor Victor Muñoz Department of Chemistry & Biochemistry A popular convention derived from early experimental evidence of single-domain proteins pointed towards a common mechanism of achieving their native threedimensional ...
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GpW is a 68-residue protein from bacteriophage λ that participates in virus head morphogenesis. Previous NMR studies revealed a novel α+β fold for this protein. Recent experiments have shown that gpW folds in microseconds by crossing a marginal free energy barrier (i.e., downhill folding). These features make gpW a highly desirable target for further experimental and computational folding studi...
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